Glucose, like mannitol, is a sugar that can behave as an osmotic diuretic.
2.
In the nephron, osmotic diuretics act at the portions of the nephron that are water-permeable.
3.
Osmotic diuretics works by expanding extracellular fluid and plasma volume, therefore increasing blood flow to the kidney.
4.
Osmotic diuretics have their major effect in the proximal convoluted tubule and the descending limb of Henle's loop.
5.
Impaction often leads to constipation and malnutrition, and possibly death unless treated promptly with laxatives such as the osmotic diuretic lactulose.
6.
In such occasions, mannitol ( osmotic diuretic ) or hypertonic saline are given to draw fluid out of the oedematus cerebrum to minimise secondary injury.
7.
It was previously believed that the primary mechanism of osmotic diuretics such as mannitol is that they are filtered in the glomerulus, but cannot be reabsorbed.
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